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  • Phenotyping of Human iPSC-derived Neurons : Patient-Driven Research
    Phenotyping of Human iPSC-derived Neurons : Patient-Driven Research

    Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices.By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design.Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement.From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis.Current treatment options for such patients are decades old and offer little relief with many side effects.One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data).To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.

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  • The Narrative Brain : The Stories Our Neurons Tell
    The Narrative Brain : The Stories Our Neurons Tell

    An investigation of the emotional power of narrative that illuminates the relationship between the human brain and the stories we tell As humans, we think in stories—stories that allow us to feel and share emotions.In order for this phenomenon to work, our brains and the ways in which we tell stories must be attuned to each other.But how exactly does this happen? Tapping into the essence of thinking in stories, Fritz Breithaupt draws on the latest scientific research, including a retelling study (comparable to the telephone game) with more than 12,000 participants, and experiments in which ChatGPT functions as storyteller.This wide-ranging study includes analyses of political history, novels, fairy tales, and everyday office gossip; proposes a new theory of narrative that focuses on emotions and affects; and hypothesizes on the evolution of narratives among our hominid ancestors.Redefining us as beings who anchor ourselves in the world through narratives, Breithaupt introduces a new kind of psychology that cuts to the core of how and why humans feel the need to tell stories.

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  • Brain-Mind : From Neurons to Consciousness and Creativity
    Brain-Mind : From Neurons to Consciousness and Creativity

    How do brains make minds? Paul Thagard presents a unified, brain-based theory of cognition and emotion with applications to the most complex kinds of thinking, right up to consciousness and creativity.Neural mechanisms are used to explain mental operations for analogy, action, intention, language, and the self. Brain-Mind develops a brilliant account of mental operations using promising new ideas from theoretical neuroscience.Single neurons cannot do much by themselves, but groups of neurons work together to accomplish powerful kinds of mental representation, including concepts, images, and rules.Minds enable people to perceive, imagine, solve problems, understand, learn, speak, reason, create, and be emotional and conscious.Competing explanations of how the mind works have identified it as soul, computer, brain, dynamical system, or social construction.This book explains minds in terms of interacting mechanisms operating at multiple levels, including the social, mental, neural, and molecular.Unification comes from systematic application of Chris Eliasmith's powerful Semantic Pointer Architecture, a highly original synthesis of neural network and symbolic ideas about how the mind works.This book belongs to a trio that includes Mind-Society: From Brains to Social Sciences and Professions and Natural Philosophy: From Social Brains to Knowledge, Reality, Morality, and Beauty.They can be read independently, but together they make up a Treatise on Mind and Society that provides a unified and comprehensive treatment of the cognitive sciences, social sciences, professions, and humanities.

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  • Neurobiological Evolution of Humans : From Neurons to Narratives
    Neurobiological Evolution of Humans : From Neurons to Narratives

    Our perception of the brain structure and function as an organ full of secrets and mysteries must change, and it is necessary to consider it as a part of the body that is constantly evolving and developing to maintain homeostasis for the entire human organism.New fossils, imaging methods, molecular genetics, comparative anatomy, evolutionary psychology, cognitive concepts in neuroscience, and neurology have made it possible to address questions of the neurological evolution of humans.This book integrates disparate findings from those disciplines in a succinct history by explaining how evolutionary process occurred, reshaped our brain, reconstructed our mind, and finally changed our "selves."Key FeaturesExplains complex scientific concepts in neurobiology using lucid prose and maintaining a clear narrativeProvides well-documented arguments supported by hundreds of references and citationsDocuments a complex history which unfolded over millions of yearsOffers new approaches intended to transform ideas, opinions, and intellectual foundations of the brain

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  • Why do I have such difficulty with the on-center neurons and off-center neurons?

    You may have difficulty with on-center and off-center neurons because they are part of the complex process of visual perception. These neurons are responsible for detecting contrast and edges in the visual field, and their interactions help to create the perception of shapes and objects. Understanding the function and interactions of these neurons requires a deep understanding of the visual system and neural processing. It is not uncommon for individuals to find this concept challenging due to its complexity and the intricate nature of neural processing in the visual system.

  • Are you familiar with mirror neurons?

    Yes, I am familiar with mirror neurons. Mirror neurons are a type of brain cell that fires both when an individual performs an action and when they observe someone else performing the same action. They are believed to play a role in understanding and imitating the actions of others, as well as in empathy and social behavior. Mirror neurons have been studied in both humans and animals, and their discovery has had significant implications for our understanding of social cognition and behavior.

  • What are the measured potentials in neurons?

    The measured potentials in neurons refer to the electrical charges that exist across the cell membrane. There are two main types of measured potentials in neurons: resting membrane potential and action potential. The resting membrane potential is the baseline electrical charge of a neuron when it is not actively sending signals, while the action potential is a brief change in electrical charge that occurs when a neuron is transmitting a signal. These measured potentials play a crucial role in the communication and functioning of the nervous system.

  • What is the chromosome set of neurons?

    Neurons have a diploid chromosome set, meaning they have two sets of chromosomes, one inherited from each parent. This diploid set of chromosomes contains all the genetic information necessary for the neuron to function and carry out its specific roles in the nervous system. The chromosomes in neurons contain the genes that encode for various proteins and molecules involved in neuronal function, communication, and signaling.

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  • Intercultural Communication : An Interdisciplinary Approach: When Neurons, Genes, and Evolution Joined the Discourse
    Intercultural Communication : An Interdisciplinary Approach: When Neurons, Genes, and Evolution Joined the Discourse

    This book is an introduction to Intercultural Communication (IC) that takes into account the much neglected dynamic paradigm of culture in the literature.It posits that culture is not static, context is the driving force for change, and individuals can develop a multicultural mind. It is also the first IC textbook in the field that incorporates insight from evolutionary biology and the newly emerging discipline of cultural neurosciences.Such an interdisciplinary approach provides readers with new angles, encourages critical thinking, and sometimes challenges conventional knowledge in the field.The combination of the author's multicultural academic and journalistic background contributes to a balance of diverse perspectives and world views on cultural theories and discourses. The book is ideal for courses in Intercultural Communication with study cases, discussion topics and class activities.

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  • Innovation Competency Model : Shaping Faculty Academic Innovation Development in China's Higher Education
    Innovation Competency Model : Shaping Faculty Academic Innovation Development in China's Higher Education

    Contributing to the discussion over China's higher education development, this book takes a theoretical approach to address the topic of university academics' innovation by introducing an academic innovation competency model, exploring the contexts, concepts and practices.The innovation competency model comprises three interdependent dimensions, including the academic internal drive vitality, the academic synthesizing refined ability and the academic suspected and introspective ability.By enriching the theory of professional development of university teachers, these three dimensions will help advance the reform of college personnel systems and ultimately improve the quality of China's higher education. The book will be valuable to researchers, students and stakeholders hoping to learn about education reform in China, or to those who study higher education management and comparative education.

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  • Gender Differences in Technology and Innovation Management : Insights from Experimental Research
    Gender Differences in Technology and Innovation Management : Insights from Experimental Research

    Even though the number of working women has steadily increased over the last few years, women are still significantly under-represented in STEM activities (i.e. mathematics, informatics, science and technology). In order to eliminate this under-representation, numerous education policies and corporate initiatives, particularly in the recent past, have been aimed at increasing women's enthusiasm for STEM activities and professions.According to the latest surveys, however, it is clear that these efforts have not yet led to the desired success.Compared to their male counterparts, women continue to do fewer STEM activities. One possible reason for this is that relatively little is yet known about the concrete impact of the above education policies on working with innovation and technology: What are the gender differences between women and men?Is it enough to recognize these differences, or should these differences ideally not only be recognized, but also treated appropriately or even encouraged? This anthology deals with current topics in technology and innovation management against the background of these and other gender-relevant aspects.Empirical analyses and experiments in collaboration with companies from various sectors provide a sound scientific basis on which new results and findings are presented: How do women and men deal with creativity and competition?How are technologies applied and how can differences in access to technology be deduced? Answers to these and other questions help decision-makers in politics and business to proactively use the differences between women and men to motivate women to work in the STEM field and to strengthen them by acknowledging existing differences.

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  • Rethinking Education for Sustainable Development : Research, Policy and Practice
    Rethinking Education for Sustainable Development : Research, Policy and Practice

    This book explores how education can be used as a tool to promote sustainability practices as the world faces huge challenges related to climate change and public health.The chapters consider all types of literacy approaches that fall under the umbrella of Education for Sustainable Development (ESD).These approaches include scientific literacy, ecological literacy, health literacy, education on climate change and climate resilience, environmental education and others linking education, global health, and the environment more broadly. “Education” is used in the widest sense to incorporate non-formal, informal and formal/school settings.This volume will help to bring these interconnected areas together and interrogate their research methods, assumptions, field-based application and their policy potential.Taking a critical approach to ESD, the book suggests new pedagogies, tools, and technologies to strengthen the way we educate about sustainability issues and go beyond the current thinking about ESD.The book includes a foreword by Jeffrey Sachs, Director of the Center for Sustainable Development at Columbia University, USA.

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  • Does unsafe behavior come from the neurons?

    Unsafe behavior can be influenced by the activity of neurons in the brain. Neurons are responsible for transmitting signals and controlling various functions, including decision-making and impulse control. When neurons are not functioning properly, it can lead to impulsive or risky behavior. Additionally, imbalances in neurotransmitters, which are chemical messengers in the brain, can also contribute to unsafe behavior. Therefore, while unsafe behavior does not solely come from neurons, their activity and communication play a significant role in influencing behavior.

  • Why are there neurons with fast signal transmission?

    Neurons with fast signal transmission, such as those found in the peripheral nervous system, are important for rapid responses to stimuli. For example, in the case of a reflex action, fast transmission allows for a quick withdrawal of a limb from a potentially harmful stimulus. Additionally, fast signal transmission is crucial for activities that require quick coordination and response, such as sports or emergency situations. Overall, neurons with fast signal transmission help to ensure the efficiency and speed of our body's responses to the environment.

  • What specific attraction is caused by mirror neurons?

    Mirror neurons are believed to be responsible for the phenomenon of empathy and understanding others' intentions and emotions. When we observe someone else performing an action, mirror neurons in our brain fire as if we were performing the action ourselves, leading to a sense of connection and understanding with the other person. This ability to resonate with others' experiences is thought to be the basis for human social behavior and the development of empathy.

  • How does the transmission of stimuli work in neurons?

    The transmission of stimuli in neurons occurs through a process called synaptic transmission. When a neuron is stimulated, an electrical signal called an action potential is generated and travels down the length of the neuron. When the action potential reaches the end of the neuron, it triggers the release of neurotransmitters into the synapse, the small gap between the sending neuron and the receiving neuron. The neurotransmitters then bind to receptors on the receiving neuron, causing a new electrical signal to be generated and continue the transmission of the stimuli. This process allows for the communication and coordination of signals throughout the nervous system.

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